Dozens of New Genes Associated With Cancer Treatment Resistance Are Identified
Using a CRISPR gene editing technique, researchers have identified dozens of new genes that create T-cell resistant cancer.
Newly Identified Genetic Mutations found in Ashkenazi Jewish Women with Breast Cancer
Comprehensive sequencing for all breast cancer genes may provide complete relevant genetic information for Ashkenazi Jewish patients.
New Genetic Mutations Linked to Breast and Ovarian Cancers
Researchers have discovered new associations between breast and ovarian cancer and genes that had not been previously detected, and which may help guide treatment decisions in the future.
Anti-Leukemic Drug Gemtuzumab Ozogamicin May Benefit Some AML Patients
A new study in JCO suggests that genetic variations within AML patients with CD33 may predict their response to gemtuzumab ozogamicin.
New Study Questions Guidelines for Genetic Screening for Prostate Cancer
Men with prostate cancer and one additional primary cancer may harbor a mutation in a cancer-predisposing gene, but the majority of these men do not meet criteria for clinical genetic testing.
Tissue-Resident Memory Cells Associated with Cytotoxic T Cell Responses
A subpopulation of T cells called tissue resident memory cells may be able to determine which cancer patients' immune systems can mount an effective anti-tumor response
TAPUR Trial Leverages Genomic Testing for Precision Medicine
In this video, Dr. Edward Kim provides details on the TAPUR trial, which uses broad genomic test results to aid in precision medicine for cancer patients.
New Tool for Predicting Treatment Response to Checkpoint Inhibitors
A two-pronged algorithm, which includes an analysis for a gene signature and tumor mutational burden, may be a potential new tool for predicting treatment response to checkpoint inhibitors.
Manipulating DNA Repair Crews to Combat Cancer
Researchers from Johns Hopkins University report on a cascade of events that appears to correlate with early cancer recurrence and decreased overall survival.
Advantage of Multigene Test for Women at Risk of Hereditary Breast Cancer
A new study is suggesting that testing for variants in seven cancer-associated genes followed by risk-reduction management could cost-effectively improve life expectancy for women at risk for hereditary breast cancer.