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Colorectal Cancer: How Emerging Molecular Understanding Affects Treatment Decisions

In this article we discuss the current treatment options in metastatic colon cancer, with a special focus on biologic agents and how molecular understanding guides treatment decisions.

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A 34-year-old man presents with a soft tissue induration in the right thigh. A biopsy of the mass is performed. What is your diagnosis?

The conversation was about metaphors for coping with cancer:

A personalized immunotherapy called chimeric antigen receptor (CAR) therapy has been given the "breakthrough therapy" designation by the U.S. Food and Drug Administration (FDA).

The use of bevacizumab or cetuximab, in combination with either the FOLFOX  (leucovorin/5-fluorouracil/ oxaliplatin) or FOLFIRI (leucovorin/5-fluoruracil/irinotecan) chemotherapy regimen, achieved similarly effective overall survival (OS)

Genetic variants could affect how cancer patients respond to radiation therapy. The results are based on a genome-wide analysis of the genetic variations among prostate cancer patients treated with external beam radiotherapy (EBRT).

What is the most common question that you are asked by patients with a new diagnosis of cancer?

43-year-old man presents with symptoms of fatigue and general malaise. Physical evaluation reveals the presence of enlarged neck lymph nodes. Biopsy of a lymph node is performed. What is your diagnosis?

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