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Managing Bortezomib-Induced Neuropathy

In this article, we discuss a common and painful side effect associated with cancer treatment.

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Heavily pretreated multiple myeloma patients responded to treatment with the oral Bruton’s tyrosine kinase (BTK) inhibitor, ibrutinib (Imbruvica) plus dexamethasone in a phase 2, open-label, dose-finding trial.

Exelixis and their partner Roche are seeking fast-tracked FDA approval for their combination therapy drug for people with BRAF V600 mutation-positive advanced melanoma.

A 45-year-old man presents with gastric pain and is found to have a gastric nodule. After further evaluation, a biopsy is performed. What is your diagnosis?

For women with triple-negative breast cancer (TNBC), adding bevacizumab (Avastin) to standard neoadjuvant chemotherapy was more beneficial for those diagnosed with basal-like tumors compared to those with nonbasal-like tumors. This data was presented at the 2014 San Antonio Breast Cancer Symposium (SABCS), being held Dec. 9-13, 2014 in San Antonio.

On December 3, 2014, the U.S. Food and Drug Administration (FDA) announced the approval of Amgen's immunotherapy drug Blincyto (blinatumomab), a bispecific T-cell engager (BiTE) used to treat patients diagnosed with Philadelphia chromosome-negative precursor B-cell acute lymphoblastic leukemia (B-cell ALL).

A 19-year-old woman presents with anterior cervical area lymphadenopathy. After further evaluation, a lymph node biopsy is performed. What is your diagnosis?

“This drug will save your life, but you have to take it every day.”I’m pretty sure it was said insensitively.    

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