A 19-year-old woman presents with anterior cervical area lymphadenopathy. After further evaluation, a lymph node biopsy is performed. What is your diagnosis?
“This drug will save your life, but you have to take it every day.”
I’m pretty sure it was said insensitively.
In May 2012, the United States Preventive Services Task Force (USPSTF) released a recommendation against prostate-specific antigen (PSA) screening for men. The justification for this recommendation was that large randomized trials demonstrated that PSA screening increased detection of prostate cancer, but there was "small to no reduction in prostate cancer-specific mortality."
I had the privilege recently of interviewing Aaron Ciechanover, MD, DSc, one of three co-recipients of the 2004 Nobel Prize in Chemistry for pioneering research that ultimately led to targeted therapy for treatment of cancer.
Pembrolizumab (Keytruda) became the leader of the PD-1 and PD-L1 antibody pack by crossing the finish line first, and successfully being granted accelerated FDA approval in September 2014 based on tumor responses and durability of the responses seen in early clinical trials.
A 48-year-old man presents with diffuse lymphadenopathy. After further evaluation, a biopsy is performed. What is your diagnosis?
In this interview, we are discussing the impact that CDK 4/6 inhibitors are having on specific types of breast cancer.
A 40-year-old woman is found to have several nodules in the liver. After further evaluation, a biopsy is performed. What is your diagnosis?
As most of you know, at the ends of chromosomes are stretches of DNA called telomeres. Each time a cell divides, it becomes shorter, losing the ability to further replicate. This shortening process is associated with not only aging and a higher risk of death, but with cancer as well.
A 68-year-old woman with a history of aggressive NHL developed hyperpigmented patches on her tongue two months after starting her R-CHOP chemotherapy regimen. Which medication was likely the cause, and which other location would you expect hyperpigmentation on this patient?
Researchers have identified a genetic mutation, known as RNF43, in two cancer types: colorectal and endometrial.
A 54-year-old man is found to have a mass in the upper pole of the right kidney. After further evaluation, a biopsy is performed. What is your diagnosis?
For those patients diagnosed with localized prostate cancer, the risk of recurrence is approximately 30%--even years after initial treatment.
A 34-year-old man presents with symptoms of appendicitis which required having his appendix removed. What is your diagnosis?
Ephrin type-A receptor 2 (EpHA2), a protein that in humans is encoded by the EPHA2 gene, is a promising target that may help identify patients who are at risk for developing aggressive colorectal cancer (CRC).